The Chii Jou Chan Lab
To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.
To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.
To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.
To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.
To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.
To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.
Chii Jou (Joe) Chan was trained in theoretical soft matter physics at the University of Cambridge (B.A., M.Phil.). For his Ph.D. with Prof. Jochen Guck at Cambridge and TU Dresden (Germany), he studied the mechanical and optical properties of living cells and nuclei, using biomechanical tools (optical stretcher, microfluidics) and biophotonics. Inspired by how physical forces shape early development of living organisms, he joined the group of Dr. Takashi Hiiragi as an EIPOD fellow at EMBL Heidelberg (Germany), where he made a major discovery in hydraulic regulation of mouse embryo size and cell fate specification. His interdisciplinary productivity is reflected in the diversity of his collaborators (cell and developmental biologists, experimental biophysicists, theorists) across the world.
Mechanobiology Institute
National University of Singapore
T-Lab, #10-01
5A Engineering Drive 1
Singapore 11273
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