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MBInsights Annual
2017 Edition
MBI Science Communications | NOV 2017
An annual summary of research at the Mechanobiology Institute, National University of Singapore
The purpose of these synopses is to show the breadth of the research coming from the MBI. We are very proud of the fact that we have been able to build an institute with state-of-the-art capabilities in super-resolution microscopy and microfabrication. Our open lab environment and the energy of our students and postdocs have combined to take advantage of our experimental tools to answer important biological questions. Because we believe that these tools should be utilized to solve many more problems in the biomedical sciences, we invite you and your colleagues to join us in collaborative studies to solve those problems. Many different disciplines are needed since the problems need the tools of physicists, biologists, computational scientists, and engineers, working side-by-side to better understand how biological systems integrate mechanical cues and physical forces from the world around them.
We hope that you find these research summaries interesting, and we invite you to join us in collaborative studies at the MBI.
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Table of Contents
A cellular shock absorber
How the structure of talin makes it an ideal force buffer
A molecular rivet for long-range force transmission
Plastin provides global connectivity to the cortex
Elongation by contraction
Pulling forces drive changes in cell shape
Decisions in a pinch
Receptor tyrosine kinases control mechanosensors
Microscopic muscles
How non-muscle cells find the strength to move
Signaling in 3D
Adding a spatial dimension to cell signaling
From the bottom up
The secret dynamics at the base of the cell
The BP(GAP) between signaling pathways
To grow or not to grow?
Persistent a-catenin activation
Force-locking adherens junction components
Stability without junctions
A new role for cadherin
Letting go
How dying cells detach from their neighbours
Illuminating the Contacts
Superresolution mapping of adherens junction machinery
Perspectives from MBI
A personal viewpoint on mechanobiology from MBI senior research fellow Rishita Changede
100 years of On Growth and Form
Celebrating a century of D’Arcy Thompson’s scientific theories and examining their influence on the field of mechanobiology
Controlling membrane waves
Rhythmic oscillations in cell biology
Defects in epithelial tissue organization
A question of life or death
To deep to divide
How cells sense depth and halt cell proliferation
A moving story of FHL2 and forces
The influence of matrix rigidity on cell growth
Breaking cell symmetry
A force driven mechanism for establishing cell polarity
HER2 can HEAR2
How the ‘deaf’ receptor hears mechanical signals
soSPIM-FCS
A novel tool for imaging nuclear protein dynamics
Modelling developmental disorders
Correctly timing cell division during embryo formation
Cellular podiatry
Understanding how cells form feet
Bailed out
How liver cells elimiate bile from blocked ducts
Development in time and space
Shedding light on the importance of time in embryo development
Cell extrusion mechanisms
How cell density affects the mechanism of extrusion
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MBInsights Annual 2017
[/fusion_title][fusion_text columns=”” column_min_width=”” column_spacing=”” rule_style=”default” rule_size=”” rule_color=”” class=”” id=””]The cover reimagines the classic image of a Nautilus shell from On Growth and Form. Here, the chambers of the shell have been replaced by cells undergoing processes commonly studied in mechanobiology, e.g. extrusion, phagocytosis, apoptosis, blebbing, and contraction. For more details, please read the feature “100 years of On Growth and Form” on pages 30-33.
Cover illustration by Diego Pitta de Araujo.
Download the 2017 edition of MBInsights Annual[/fusion_text][fusion_separator style_type=”single solid” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”” top_margin=”” bottom_margin=”80px” border_size=”0″ icon=”” icon_circle=”” icon_circle_color=”” width=”60%” alignment=”center” /][fusion_button link=”” title=”” target=”_self” link_attributes=”” alignment=”left” modal=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” color=”default” button_gradient_top_color=”” button_gradient_bottom_color=”” button_gradient_top_color_hover=”” button_gradient_bottom_color_hover=”” accent_color=”” accent_hover_color=”” type=”” bevel_color=”” border_width=”” size=”medium” stretch=”yes” shape=”” icon=”” icon_position=”left” icon_divider=”no” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=””]More Issues[/fusion_button][fusion_person name=”” title=”” picture=”https://mbi.closelycoded.site/wp-content/uploads/2016/10/MBInsights-magazine-cover-oct2016-v2.jpg” pic_link=”https://mbi.closelycoded.site/wp-content/uploads/2017/04/MBInsights2016.pdf” linktarget=”_self” pic_style=”none” hover_type=”none” background_color=”” content_alignment=”” pic_style_color=”” pic_bordersize=”” pic_bordercolor=”” pic_borderradius=”0″ icon_position=”” social_icon_boxed=”” social_icon_boxed_radius=”” social_icon_color_type=”” social_icon_colors=”” social_icon_boxed_colors=”” social_icon_tooltip=”” blogger=”” deviantart=”” digg=”” dribbble=”” dropbox=”” facebook=”” flickr=”” forrst=”” googleplus=”” instagram=”” linkedin=”” myspace=”” paypal=”” pinterest=”” reddit=”” rss=”” skype=”” soundcloud=”” spotify=”” tumblr=”” twitter=”” vimeo=”” vk=”” xing=”” yahoo=”” yelp=”” youtube=”” email=”” show_custom=”no” custom_4=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” /][fusion_separator style_type=”none” top_margin=”20px” alignment=”center” /][fusion_title margin_top=”” margin_bottom=”20px” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” size=”3″ content_align=”left” style_type=”none” sep_color=””]
MBInsights Annual 2016
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The cover depicts the formation of the actin rim around the nucleus in response to a distant force, which may act as a shield to protect DNA from mechanical forces and stabilize nuclear functions. For more details, please read the feature “Forces Acting Far and Wide” on pages 14-15.
Cover illustration by Diego Pitta de Araujo.
Download the 2016 edition of MBInsights Annual
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