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Wong Bin Sheng

Research Fellow, Mechanobiology Institute, National University of Singapore

mbiws@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

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Wong Bin Sheng

Research Fellow

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Principal Investigator

Rong Li

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Research Areas:

Cell migration, Cell cycle and mitosis, Cell mechanics and dynamics

Qualifications:

Biography:

Bin Sheng received his B.Sc. in Pharmacy with First Class Honours from NUS (2009-2013), and graduated with a Ph.D. in Chemical and Biomolecular Engineering from JHU under the guidance of Professor Konstantinos Konstantopoulos (2013-2019). By employing an interdisciplinary approach that combines bioengineering and microfabrication, molecular and cell biology, biochemistry, quantitative image analysis and in vivo preclinical models, his doctoral research focused on understanding the biochemical and physicomechanical mechanisms of cell migration and how these basic science discoveries can be translated into potential clinical tools against cancer metastasis.

He is currently a postdoctoral research fellow for Professor Rong Li at the Mechanobiology Institute, NUS (2020-now), where he is extending his research to the area of mechanobiology and cellular dynamics. Specifically, he is working on understanding how mammalian cells behave and adapt to chromosomal imbalance and chronic osmotic stress.

Technical Skills:

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Selected Publications

  1. Tuntithavornwat, S., Shea, D. J., Wong, B. S., Guardia, T., Lee, S. J., Yankaskas, C. L., … & Konstantopoulos, K. (2022). Giant obscurin regulates migration and metastasis via RhoA-dependent cytoskeletal remodeling in pancreatic cancer. Cancer letters, 526, 155-167. https://doi.org/10.1016/j.canlet.2021.11.016
  2. Wong, B. S., Shah, S. R., Yankaskas, C. L., Bajpai, V. K., Wu, P. H., Chin, D., … & Konstantopoulos, K. (2021). A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma. Nature Biomedical Engineering, 5(1), 26-40. https://doi.org/10.1038/s41551-020-00621-9
  3. Guerrero, P. E., Miró, L., Wong, B. S., Massaguer, A., Martínez-Bosch, N., Llorens, R. D., … & Peracaula, R. (2020). Knockdown of α2, 3-sialyltransferases impairs pancreatic cancer cell migration, invasion and e-selectin-dependent adhesion. International Journal of Molecular Sciences, 21(17), 6239. https://doi.org/10.3390/ijms21176239
  4. Wong, B. S., Shea, D. J., Mistriotis, P., Tuntithavornwat, S., Law, R. A., Bieber, J. M., … & Konstantopoulos, K. (2019). A direct podocalyxin–dynamin-2 interaction regulates cytoskeletal dynamics to promote migration and metastasis in pancreatic cancer cells. Cancer Research, 79(11), 2878-2891. https://doi.org/10.1158/0008-5472.can-18-3369
  5. Wong, B. S., Mistriotis, P., & Konstantopoulos, K. (2018). Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration. Biomechanics in Oncology, 139-157. https://doi.org/10.1007/978-3-319-95294-9_8

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